A new discovery has reshaped our understanding of PCR chip technology: water vapor, not air expansion, is the primary culprit behind bubble formation in polydimethylsiloxane (PDMS)-based chips. This revelation has led to the development of a high-pressure liquid seal technique that effectively eliminates bubbles and prevents water loss during the polymerase chain reaction (PCR) process.New PCR Chip Design: High-Pressure Liquid Seal Solves Bubble Problem
April 15, 2025
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A new discovery has reshaped our understanding of PCR chip technology: water vapor, not air expansion, is the primary culprit behind bubble formation in polydimethylsiloxane (PDMS)-based chips. This revelation has led to the development of a high-pressure liquid seal technique that effectively eliminates bubbles and prevents water loss during the polymerase chain reaction (PCR) process.
